Medical & Pharmaceutical

Event Profile: There is no better way for UK medical device manufacturers to effectively and efficiently see, compare, and evaluate the complete range of product and service resources for designing and manufacturing current and next-generation medical devices and equipment (Medtec UK) Highlights: Content for the technical conference changes year-on-year and topics are generated through delegate and industry feedback. Visitor's Profile: Pharma Formulators, API, Drug Intermediates, Excipients, Natural Extracts, Contract Researchers, Custom Manufacturers, Packaging Equipment / Materials, Quality Assurance & Control, Product Development Services, Laboratory & Processing Equipment Manufacturers, Trade Publications, Contract Research, Contract Processing are the target audience. Exhibitor's Profile: Contract Manufacturing & Subcontracting, Component Fabrication, Tubing Adhesives & Adhesive Products, Electronic Components, Production/Assembly, Packaging Equipment & Materials, Motors & Motion Control, Plastics Testing Equipment & Services Hardware & IV Components Precision Metalworking, Tooling, and Machining Organizer: Canon Communications 11444 W. Olympic Blvd., Ste. 900, Los Angeles, United States of America. Tel: +(310)-(4)-454200 Fax: +(310)-(4)-454299

Achieving NHS Productivity 27 to 28 February 2008 Manchester, United Kingdom Website: http://www.hsj-productivity.co.uk Contact name: Customer Service Health Service Journal brings you two one-day conferences that focus on achieving productivity in the NHS. Tackling two key service areas - theatres and wards. Organized by: HSJ Conferences

3 days of site-visits to innovative geriatric facilities with renowned lecturers from around the country. Sites include unique retirement villages, sheltered housing, day care centers, snoezelen rooms and the Savion computer program for mental stimulation for people with Alzheimer's disease. Topics covered in lectures : Historical survey of Geriatric Care in Israel, how various ethnic groups care for their aged. Additional Information Tour begins in Jerusalem and continues on to Beer Sheva and returns to jerusalem. Includes transportation from jerusalem, food and lodgings for 3 days and two nights of tour. Accommodations in kibbutz guest houses &/ or hostels. $450 per person - early bird discount $380, for payment by Oct. 30.

SPECIFIC OBJECTIVES – DAY 1 - CLINICAL AND LABORATORY APPROACH TO RHEUMATIC DISEASES – Approach to the evaluation of the patient with rheumatic disease including: Relate the central role of the history and physical examination. Key x-ray findings in patients with rheumatic diseases. Importance of synovial fluid analysis. Use and limitations of laboratory testing. OSTEOARTHRITIS: DIAGNOSIS AND TREATMENT – Distinguish osteoarthritis from other forms of arthritis. Appropriate use of medical, physical and surgical treatments. MANAGEMENT OF TYPE 1 DIABETES – Diagnostic criteria for the diagnosis of diabetes. New insulin regimens for intensive glucose control. Screen for and manage cardiovascular complications of diabetes based on evidence-based studies. TREATMENT STRATEGIES IN TYPE 2 DIABETES – New pharmacologic agents available for glucose control. Apply concepts of pathophysiology to the selection of pharmacotherapy for Type 2 diabetes. Cost-effective approach to the management of diabetic complications. DAY 2 - POLYCYSTIC OVARY SYNDROME – Concepts in risk factors and pathophysiology. Simple laboratory screening process for diagnosis. Apply pathophysiology to design a treatment strategy. ADRENAL CASE STUDIES – Evaluation of the incidental adrenal mass. Diagnose and treat adrenal insufficiency. Manage patients with excessive adrenal steroid levels. CLINICAL ASPECTS OF RHEUMATOID ARTHRITIS – Clinical features of rheumatoid arthritis. The systemic nature of the disease. TREATMENT OF RHEUMATOID ARTHRITIS – Approach to the treatment of rheumatoid arthritis. Use and toxicity of disease modifying agents. DAY 3 - CRYSTAL ARTHROPATHIES – Describe the diagnosis and treatment of crystal arthropathies including gout and pseudogout. OSTEOPOROSIS: EVALUATION AND TREATMENT – Pathophysiology and epidemiology of osteoporosis. Role of bone mineral density measurement in the diagnosis of osteoporosis. Nonpharmacologic and pharmacologic treatments for osteoporosis. THE DYSLIPIDEMIAS: EVIDENCE-BASED DECISION MAKING – Landmark outcomes studies in reducing cardiovascular risk. Lipid lowering therapies. Apply evidence based protocols to at-risk patients. DISORDERS OF CALCIUM METABOLISM – Differential diagnosis of hypercalcemia. Cost effective workup to elevated calcium states. Evaluate hypocalcemic disorders using common laboratory studies. DAY 4 - THYROID CASE STUDIES, PARTS 1 & 2 – Etiologies and pathogenesis of hyper and hypothyroidism. Cost effective principles in the laboratory evaluation of thyroid conditions. Treatment protocols for various thyroid conditions. PSORIATIC ARTHRITIS AND THE SPONDYLOARTHROPATHIES – Clinical features of psoriatic arthritis and the spondyloarthropathies. Treatment modalities. SYSTEMIC LUPUS AND CONNECTIVE TISSUE DISEASES – Varied clinical presentations of SLE, Scleroderma and Myositis. Use of laboratory testing in diagnosis. Treatment options in systemic lupus erythematosus. DAY 5 - VASCULITIS – Clinical manifestations of the various vasculitides and diagnostic evaluation. Treatment modalities used in vasculitis. SOFT TISSUE RHEUMATOLOGY – Diagnosis and treatment of soft tissue rheumatic conditions. Clinical aspects of entrapment neuropathies and their association with systemic conditions. MALE HYPOGONADISM CLINICAL FEATURES – “Male menopause”. Cost-effective strategy to investigate causes of male hypogonadism. Treat various endocrine conditions arising in men. PITUITARY POTPOURRI – Differential diagnosis based on clinical features. Laboratory workup using a “best test” approach. Treatment options.

SPECIFIC OBJECTIVES – DAY 1 - HYPERTENSIVE UPDATE: CREEPING UP ON A SILENT KILLER – JNC guidelines in the treatment of hypertension. Selection of different antihypertensive agents in select subgroups of patients. The newest antihypertensive agents and the rationale for choosing these over older agents. ANEMIA – Guidelines for diagnosing anemia in children and adults. Common diagnostic studies available for diagnosing the etiology of the anemia. Role of consultants in the evaluation and management of anemia. COMMUNITY ACQUIRED PNEUMONIA: DIAGNOSING AND TREATING THE #1 CAUSE OF DEATH IN THE U.S. FROM INFECTIOUS DISEASES – How to stratify your patients with CAP into those needing outpatient (most) vs. inpatient (few) treatment, using the PORT scoring system. Antibiotic options in treating CAP including the role of respiratory tract fluoroquinolones, and newest macrolide agents as well as more conventional therapies. Role and timing of ordering chest x-rays, blood cultures and initiation of antibiotic therapy. DEPRESSION IN PRIMARY CARE – The incidence and prevalence of anxiety and depression. Signs and symptoms associated with anxiety and depression. Treatment strategies available. DAY 2 - ASTHMA – Epidemiology of asthma. Modalities to diagnose asthma. Different treatments for asthma, both pharmacological and environmental. CURRENT TRENDS IN THE DIAGNOSIS AND TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE – Increase awareness of the large number of your patients who suffer from COPD, and who are currently going undiagnosed. Diagnose those with COPD within a single office visit. Current GOLD guidelines, in the diagnosis and treatment of those with COPD. CORONARY ARTERY DISEASE – Common presenting symptom complexes of patients. The diagnostic evaluation of a patient with chest pain. Current medication and surgical treatment options. CARE OF THE DIABETIC PATIENT – Benefits of a multidisciplinary approach to the management of DM and the critical role of the Primary Care Physician. Latest diagnostic criteria for diagnosing diabetes. Newest medications in the treatment of diabetes. DAY 3 - URINARY TRACT INFECTIONS – Uncomplicated and complicated UTIs, and why it is important to differentiate between the two. Importance of antimicrobial resistance when treating those with UTIs. Current guidelines in the treatment of uncomplicated cystitis, pyelonephritis and asymptomatic bacteriuria. IDENTIFICATION AND TREATMENT OF TRAUMATIZED PATIENTS – Characteristics associated with traumatic events. The “red flags” or symptomatic manifestations of trauma in patients. How to obtain a trauma history from a patient. Interventions designed to treat the symptoms of trauma. COLON CANCER PREVENTION – Patients who are at average and above average risk for developing colon cancer. Benefits and shortcomings of currently available means of colon cancer screening: from simple FOBT and genetic stool analysis to virtual colonoscopy and conventional colonoscopy. Latest advances in colon cancer screening. IMPROVING COMPLIANCE – Patient/physician communication issues that enhance compliance. Techniques to increase compliance. Follow-up plan for each STI. DAY 4 - EATING DISORDERS – Behavioral and psychosocial triggers that promote eating disordered behaviors. Anorexia, bulimia and binge eating behaviors. Clinical “red flags” that indicate eating disordered behavior. Interventions designed to treat eating disordered behaviors. DEVELOPMENTAL SCREENING OF INFANTS AND YOUNG CHILDREN – Prevalence of developmental and behavioral disorders in children. Standardized developmental screening tools available for use. Strategies to provide periodic screening in the office based setting. ADULT HEALTH SCREENING UPDATE – Current primary care guidelines for recommended screening tests for adults. Recommended immunizations for adults. FEVER IN THE YOUNG INFANT – Common etiologies of serious bacterial infection in neonates and infants and select appropriate therapies. Evaluation of the febrile neonate and infant, and differences in published criteria. The intolerance of serious bacterial infection in the neonate and infant. DAY 5 - SMOKING CESSATION – Role of smoking in disease etiology. Smoking cessation techniques. CARING FOR THE ADOLESCENT PATIENT – Strategy for conducting adolescent interviews that will address appropriate confidentiality issues. Prevalence of various at risk behaviors in the adolescent patient. Sexual maturity ratings for puberty and when delayed sexual maturity should be suspected. OBESITY – Epidemiology of obesity in America and the health risks associated with obesity. Patients that are obese and that are in need of treatment. Treatment options available, including diet, exercise, medications, and bariatric surgery. PEDIATRIC IMMUNIZATIONS AND SCREENING – Appropriate pediatric screening to be done during the first five years of life. Appropriate immunizations and time of immunizations for this age group.

SPECIFIC OBJECTIVES – DAY 1 - NEW AND CHANGING DISEASES – Etiology and pathogenesis of these infections. Clinical approach and methods of diagnosing these infections. Management of these infections. HERPESVIRUS INFECTIONS – Clinically pertinent aspects of herpesvirus infections. Syndromes, clinical complications and attributes of recurrent disease. Management and use of anti-virals. VIRUSES TO BE COVERED INCLUDE – Herpes simplex virus; Epstein-Barr virus; Cytomegalovirus; Varicella-zoster virus; HHV6. URINARY TRACT INFECTION – Epidemiology of UTIs. Attributes of lower tract and upper tract infections and reinfections and relapses. Chronic bacterial prostatitis. Approach to antimicrobial therapy, to include the use of short course therapy. Approach to prevention. PROPHYLAXIS OF ENDOCARDITIS AND PROSTHETIC JOINTS: ISSUES FOR PRIMARY CARE – Current recommendations for antibiotic prophylaxis of endocarditis and prosthetic joints. Data supporting prophylaxis. Appropriate patients for prophylaxis. Administration of prophylactic antibiotics. Prophylaxis in the allergic patient. SEXUALLY TRANSMITTED DISEASES – Current understanding of the epidemiology of common STDs. Attributes of clinical presentations. Diagnostic approaches. Current treatment recommendations. DAY 2 - HEPATITIS – Pathogenesis and clinical manifestations of hepatitis A, B, C, D or E. Differences in rates of complications. Treatment options for hepatitis B, C and their rates of success. TRAVEL HEALTH – General preventive measures including what not to eat and drink. Immunizations. Prevention of malaria, diarrhea and other illnesses of travelers. Management of diarrhea of travelers. HELICOBACTER PYLORI INFECTION – Clinical manifestations . Methods of diagnosing. Treatment. INFECTIVE DIARRHEA – Presentation of toxigenic and invasive diarrhea. Food-borne pathogens. When to use fecal WBC, stool cultures, and stool O&P examinations. Indications for antibiotic therapy. Appropriate antibiotic choices. ILLUSTRATIVE CASES – Expected clinical manifestations of the disorders presented. Appropriate therapeutic regimen for each case. Contraindications or possible resistance problems, if any, with each case. Expected outcomes of therapy for each case study. DAY 3 - NEWER ANTIBIOTICS – The antibacterial spectrum of activity. Pharmacology of the agents. Indications and dosing recommendations. Side effects, adverse reactions and drug interactions. ADULT IMMUNIZATIONS – Current recommendations for the following vaccine preventable diseases: influenza, pneumococcal infection, hepatitis B, hepatitis A, varicella-zoster, and meningococcal infection. UPDATE ON ANTIMICROBIAL RESISTANCE – Pattern of emergence of resistance to certain infecting bacteria. Epidemiology that may indicate potential resistance among the organisms discussed such as: Staphylococci; Pneumococci; Enterococci; Gram negative bacilli. Approach to current therapeutic regimens while considering resistance. HIV PRIMER FOR THE PRIMARY CARE PHYSICIAN – Latest epidemiology of HIV infection. Utility of diagnostic tests (e.g. viral load, CD4 count) and their application for disease management. Principles of antiretroviral treatment and currently available medications. Prophylaxis to prevent opportunistic infections. ILLUSTRATIVE CASE STUDIES – Expected clinical manifestations of the disorders presented. The appropriate therapeutic regimen for each case. Contraindications or possible resistance problems, if any, with each case. Expected outcomes of therapy for each case study. DAY 4 - COMMUNITY ACQUIRED PNEUMONIA – Microbial causes of community acquired pneumonia. Accepted methods, and potential pitfalls of making the diagnosis. Prognostic factors related to outcome. Treatment options according to severity of illness. SOFT TISSUE INFECTIONS: CELLULITIS, FASCIITIS AND THE DIABETIC FOOT – Typical and atypical manifestations. Pathogenesis. Principles of medical and surgical treatment. Prognosis. TUBERCULOSIS – Groups at risk for developing active tuberculosis. Principals of antituberculous therapy. Mantoux technique for tuberculin skin testing. Indications for treatment of latent TB infection. WHAT THE PRIMARY CARE PHYSICIAN SHOULD KNOW ABOUT ACUTE MENINGITIS – Epidemiology of meningitis and the different types of meningitis. Clinical signs and symptoms of different types of meningitis. Indications for lumbar puncture (LP) and interpretations of LP results. Treatment options and the need for hospitalization and public health notification. ILLUSTRATIVE CASES – Expected clinical manifestations of the disorders presented. Appropriate therapeutic regimen for each case. Contraindications or possible resistance problems, if any, with each case. Expected outcomes of therapy for each case study.

SPECIFIC OBJECTIVES – DAY 1 - Elements of a lawsuit including: Duty; Breach; Injury; Causation. Discuss torts as they developed from the common law of England and the United States. Evolution of the standards of medical care from local to national standards. Legal theories used to establish liability of medical providers. DAY 2 - The process through which a complaint is filed and evidence obtained. How the defense responds to the complaint. Constructive behaviors as they relate to legal procedures. Strategy and objectives for both plaintiff and defendant during the litigation process. DAY 3 - Components of the actual trial process. Interests of the liability insurer and interests of the physician defendant. Various forms of alternative dispute resolution for settlement of claims. DAY 4 - The plaintiff’s claims concerning damages. The defenses utilized to rebut plaintiff’s claims for damages. Partial but representative list of the types of legal claims physicians frequently encounter. Methods that can minimize the potential of a liability claim being brought against the physician. DAY 5 - The legal importance of the medical record for the plaintiff and defendant. Methods to improve charting and the ability to defend one’s care. How the National Health Practitioners Data Bank affects Medicolegal encounters. Various areas in medicine or practice behaviors that predispose to high risk for medical malpractice claims. Situations or patient encounters that commonly result in behavior consistent with high risk for causing an action. Strategies and resources available when a perceived high risk behavior or encounter has occurred.

SPECIFIC OBJECTIVES: TOPIC 1: FEVER AND RASH - Identify common and uncommon rashes associated with fever in children and infants. Enumerate those historical clues that are helpful in evaluating difficult to identify rashes. TOPIC 2: PEDIATRIC EKG WORKSHOP - Contrast normal adult and pediatric EKGs. Describe the transition from pediatric to adult EKG pattern. Identify important pediatric EKG abnormalities. TOPIC 3: PEDIATRIC PRESENTATIONS OF CARDIAC DISEASE - Recognize common clinical scenarios indicating the presence of cardiac disease in children. Review the pathophysiology of some common pediatric heart diseases. TOPIC 4: VISUAL DIAGNOSIS - Recognize common, uncommon and atypical presentations of childhood illnesses. Formulate an initial approach to the management of certain childhood illnesses or injuries based on visual clues. Ask appropriate questions to discriminate among similar appearing pediatric diagnoses. TOPIC 5: PEDIATRIC PAIN MANAGEMENT AND SEDATION - Name the common pharmacologic agents used for pediatric pain relief and sedation. Describe the side effects and contraindications for the specific medications used for pain relief and sedation. Select an appropriate sedative plan for specific situations requiring sedation. TOPIC 6: ORTHOPEDICS IN THE PEDIATRIC PATIENT - Describe the anatomic differences between child and adult bones/joints. Classify pediatric fractures involving the growth plate. Identify fractures associated with abuse. Treat common orthopedic injuries and know when to refer. TOPIC 7: JUDICIOUS USE OF ANTIBIOTICS IN THE OUTPATIENT SETTING - Identify antibiotic prescribing patterns, outcomes, and expenditures for common pediatric conditions. Compare parent and physician beliefs for prescribing antibiotics.

New pathways, new systems, new services, new roles… the Urgent Care agenda is radically transforming emergency and unscheduled services as we’ve known them, and fast. Transcending the old boundaries of A&E and ambulance services, urgent care’s wide web of activities and providers hold the potential to achieve far more than meeting waiting time targets. Trusts nationally are now breaking silo thinking to deliver care in more convenient places, meet a wider spectrum of patient needs, and realise a new vision of emergency and unscheduled care provision. Many challenges are involved, however, in transcending previous standards and innovating care delivery in this large and complex service area. Understanding the needs of both managers and clinicians involved in urgent care, HSJ proudly brings you its annual best practice forum. This key event will condense and deliver the resources and up-to-the-minute guidance you need, to maintain momentum in implementing the urgent care agenda in your health community. Gain exclusive expert guidance on the very latest urgent care agenda, as strategy sessions and case studies empower you to: * Fortify, ring-fence and integrate your ambulance and out-of-hours services and co-locate primary care within A&E * Harness and implement new technology to link patient data systems and navigate streamlined pathways – from CMS to Hear and Treat * Master capacity and demand management and intelligently commission a system of multiple urgent care providers * Pioneer proven social marketing strategies to direct the public to the most appropriate services in urgent care * Achieve collaboration between mental health services and urgent care * Build a strong business case for your urgent care investment and develop a commercial instinct within the NHS Join your colleagues and the experts as you explore the latest DH guidance, learn from best-practice, and take home the strategies and practical tools that will unite your urgent care providers in efficiency, collaboration and innovation.

A Two-Day Comprehensive & Interactive Course with Workshops on: - FDA's Center for Devices and Radiological Health Investigations - Clarifying FDA Classification of Medical Devices - Memoranda of Understanding (MOU) - Developing QSR/GMP/ISO for combo products - Principals of ICH GCP for Medical Devices - Definitions and Classifications of Medical Device - The Premarket Notification (510K) Summaries and Reviews - Investigational Device Exemption (IDE) Applications - Premarket Approval (PMA) Review Process - Safety and Effectiveness Requirements - Humanitarian Device Exemption (HDE) - Post Market Obligations - Managing Recalls and Problem Reporting - Planning and Implementing an Clinical Audit - Determining a Regulatory Strategy - Clinical Trials for Medical Devices - Sponsor Obligations - Inspection and Audit of Vendors - FDA Notification procedures Distinguished Course Leaders Martha A. Feldman, RAC President & CEO Drug & Device Development Co., Inc. Albert A. Ghignone, MS, RAC CEO AAG Incorporated